Medication Directory

• Focal epilepsy in patients 16 years or older

• Rash
• Swelling
• Feeling sad
• Depression/suicidal thoughts

• Monotherapy and adjunctive for focal epilepsy and generalized tonic-clonic seizures
• Trigeminal neuralgia
• Contra-indicated in absence and myoclonic seizures

• Changes in blood cell counts
• Sleepiness, dizziness, blurred vision
• Vomiting, diarrhea, constipation
• Depression/suicidal thoughts

• Adjunctive for LGS in patients two years or older

• Serious Skin rash/Stevens-Johnson Syndrome
• Trouble using the bathroom,
• Tiredness
• Suicidal thoughts/depression

• Monotherapy or Adjunctive for LGS, akinetic and myoclonic seizures,
• Refractory absence seizures
• Panic disorder
• Periodic leg movement
• Neuralgia

• Drowsiness
• Withdrawal seizures
• Depression/Suicidal behavior
• Tolerance is common in long-term use: seizures may recur and require dosage increases

• Adjunctive treatment of focal seizures
• Treatment for anxiety disorders
• Acute alcohol withdrawal

• Depression: sleepiness, behavioral issues
• Suicidal behavior/ideation
• Withdrawal seizures/status
• Trouble sleeping, nervousness

• Adjunctive or monotherapy treatment for focal seizures (age 18+)

• Rash,
• Dizziness
• Extreme tiredness
• Depression/suicidal behavior

• Absence Epilepsy (age 3 and older)

• Abnormalities in liver and kidney function
• Nausea, abdominal discomfort, drowsiness, anorexia, headache, rash
• Depression/Suicidal behavior

• Generalized tonic-clonic seizures and focal seizures

• Liver damage
• Depression/Suicidal behavior

• Focal epilepsy
• Primary and Adjuvant for LGS
• Contraindicated in blood and hepatic
• Last resort drug.

• Rarely causes blood counts to go down and liver failure
• Anorexia, vomiting, trouble sleeping, headache, dizziness
• Drug rash
• Depression/Suicidal behavior

• Adjunctive therapy in focal seizures with sec GTC > 12 yo and focal seizures in 3-12 yo
• Trigeminal neuralgia and postherpetic neuralgia

• Dizziness, fatigue,
• Dose-related weight gain
• Depression/Suicidal behavior

• Monotherapy or Adjuvant therapy for focal onset epilepsy age >17.

• Dizziness, headaches, nausea
• Severe cardiac disease
• Depression/Suicidal behavior

• Adjunctive tx for focal seizures, primary generalized tonic-clonic seizures, LGS (> 2 yo)
• Monotherapy  for focal seizures for those who have tried 1st generation AEDs (> 16 yos)
• Bipolar disorder ( > 18 yo)

• Serious Skin rash/Stevens-Johnson Syndrome
• Mild tremor
• Headache
• Insomnia
• Dizziness
• Depression/Suicidal behavior

• Adjunctive tx for focal onset seizures (>4 yo)
• Adjunctive tx for myoclonic seizures in JME (>12 yos)
• Adjunctive tx for primary GTC (>6 yo)

• Coordination difficulties
• Behavioral problems
• Depression/Suicidal behavior

• Monotherapy or adjunctive tx for focal onset seizures in adults and 4-16 yos.
• Not for 1° gen epilepsy because it worsens myoclonic and absence seizures
• Trigem neuralgia

• Dizziness, headache, nausea, vomiting
• Blurred vision, tremor
• Depression/Suicidal behavior
• Rash and Stevens-Johnson syndrome

• Monotherapy tx for focal onset seizures ± GTC (> 12 yos)
• Adjunctive for PGTC (>12yo)

• Mood changes and irritability
• Dizziness, fatigue, falls
• Nausea
• Weight gain

• Focal onset seizures and generalized tonic-clonic seizures
• Neonatal seizures
• Status epilepticus
• Sedation
• Not usually used chronically due to dose-related side effects

• Depression/Suicidal behavior
• Withdrawal seizures if stopped abruptly

• Focal epilepsy with generalized tonic-clonic seizures
• Focal epilepsy seizures
• Status epilepticus

• Extreme tiredness
• Abnormal movements
• Confusion, cognitive changes
• Depression/Suicidal behavior

• Adjunctive tx for partial seizures in adults
• Diabetic neuropathic pain
• Post-herpetic neuralgia
• fibromyalgia

• Weight gain, poor concentration
• Blurred vision
• Depression/Suicidal behavior

• Monotherapy and Adjuvant tx for generalized tonic-clonic, focal and psychomotor seizures (> 8 yo)
• Refractory GTCs
•  Essential tremor

• Sleepiness, rash, nausea/ vomiting
• Depression/Suicidal behavior

• Adjunctive tx of seizures with LGS in > 4 yos

• Contra-indicated in Familial Short QT syndrome
• Headache
• Dizziness
• Depression/Suicidal behavior

• Adjunctive therapy for partial seizures (over age 12)
• Not for patients with primary generalized epilepsy as may worsen myoclonus and absence seizures

• Tiredness, dizziness, headache, tremor, abnormal thinking
• Seizures in patients without epilepsy: new onset seizures
• Depression/Suicidal behavior

• Monotherapy and adjunctive tx in focal or primary GTC seizures (> 2 yo)
• Adjuvant for LGS (> 2 yo)
• Migraines in adults

• Somnolence
• Weight loss
• Speech disturbance
• Dizziness
• Depression/Suicidal behavior

Trokendi™ XR

Qudexy™ XR

• Monotherapy in  ≥ 10 yo with focal or primary GTC, LGX in pts ≥ 6 yo

Qudexy XR:

• Monotherapy in ≥ 10 yo for focal or primary GTC, adjunctive in pts ≥ 2 yo for focal or primary GTC, adjuvant for LGS ≥ 2 yo

• Depression/Suicidal behavior
• Somnolence, tiredness
• Weight loss
• Speech disturbance
• Dizziness

Divalproex sodium (Depakote®, Depakote ER®)

• Monotherapy and Adjunctive tx for focal onset seizures
• Monotherapy and Adjunctive tx for focal onset seizures with and without loss of consciousness
• Adjunctive for multiple seizure types that include absence seizures

• Liver failure, pancreatitis
• High risk of major congenital malformations in children of women taking valproic acid
• Drowsiness
• Nausea, vomiting, weight gain, transient hair loss
• Depression/Suicidal behavior

• Adjunctive tx for refractory focal epilepsy in adults who have failed other alternatives
• Monotherapy for infantile spasms, especially in TS

• Progressive and permanent visual field constriction requires consent
• Depression/Suicidal behavior
• Tiredness
• Weight gain
• Tremor

• Adjunctive therapy for partial seizures in adults with epilepsy
• May be effective in myoclonus (not approved in US)

• Rash/Stevens-Johnson syndrome
• Weight loss, dizziness, eating problems, slowed thinking
• Depression/Suicidal behavior